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Home - Products - Angiogenesis - c-Met/HGFR - Cabozantinib hydrochloride

Cabozantinib hydrochloride

CAS No. ——

Cabozantinib hydrochloride ( XL184 | BMS-907351 )

Catalog No. M19952 CAS No. ——

Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2 c-Met Kit Axl and Flt4 (IC50s: 0.035 1.3 4.6 7 and 6 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 49 Get Quote
5MG 70 Get Quote
10MG 108 Get Quote
25MG 188 Get Quote
50MG 283 Get Quote
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Biological Information

  • Product Name
    Cabozantinib hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2 c-Met Kit Axl and Flt4 (IC50s: 0.035 1.3 4.6 7 and 6 nM).
  • Description
    Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2 c-Met Kit Axl and Flt4 (IC50s: 0.035 1.3 4.6 7 and 6 nM).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    XL184 | BMS-907351
  • Pathway
    Angiogenesis
  • Target
    c-Met/HGFR
  • Recptor
    c-Kit| c-Met| VEGFR2/KDR| FLT4| Axl|RORγ|RORα
  • Research Area
    Cancer
  • Indication
    Adrenocortical carcinoma; Bone metastases; Brain metastases; Breast Cancer; Cholangiocarcinoma; Endometrial Cancer; Ewing's sarcoma

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    537.96
  • Molecular Formula
    C28H25ClFN3O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 80 mg/mL
  • SMILES
    Cl.COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yakes FM et al. Cabozantinib (XL184) a novel MET and VEGFR2 inhibitor simultaneously suppresses metastasis angiogenesis and tumor growth. Mol Cancer Ther 2011 10(12) 2298-2308.
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